Table 3. Bivariate and multivariate analyses of independent variables with multinomial pregnancy outcome for women in Zika virus epidemic, Dominican Republic, 2016–2017*.
| Characteristic | Birth outcome |
p value by χ2 test | Bivariate crude OR (95% CI) |
Multivariate adjusted OR (95% CI), n = 786 |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Miscarriage or IUFD, n = 70 | Premature live birth, n = 78 | Term live birth, n = 638 | Fetal loss vs. term live birth | Premature vs. term live birth | Fetal loss vs. term live birth | Premature vs. term live birth | |||
| Maternal age, y | |||||||||
| >30 | 24 (34.3) | 20 (25.6) | 162 (25.4) | 0.27 | 1.53 (0.91–2.59) | 1.01 (0.59–1.74) | 1.48 (0.86–2.56) | 1.02 (0.60–1.76) | |
|
<30 |
46 (65.7) |
58 (74.4) |
476 (74.6) |
NA |
NA |
NA |
|
NA |
NA |
| Residence in Greater Santo Domingo† | |||||||||
| Yes | 27 (38.6) | 39 (50.0) | 262 (41.1) | 0.27 | 0.90 (0.54–1.50) | 1.44 (0.90–2.30) | NA | NA | |
| No |
43 (61.4) |
39 (50.0) |
376 (58.9) |
NA |
NA |
NA |
|
NA |
NA |
| Diagnosis | |||||||||
| Confirmed | 26 (37.1) | 21 (26.9) | 152 (23.9) | 0.05 | 1.88 (1.12–3.16) | 1.18 (0.69–2.00) | NA | NA | |
| Suspected |
44 (62.9) |
57 (73.1) |
485 (76.1) |
NA |
NA |
NA |
|
NA |
NA |
| Timing of suspected Zika infection, wks gestation | |||||||||
| <12 | 46 (65.7) | 22 (28.2) | 156 (24.4) | <0.0001 | 5.92 (3.50–10.0) | 1.21 (0.72–2.05) | 5.92 (3.49–10.0) | 1.22 (0.72–2.07) | |
| >12 |
24 (34.3) |
56 (71.8) |
482 (75.6) |
NA |
NA |
NA |
|
NA |
NA |
| Symptoms‡ | |||||||||
| Rash | 60 (85.7) | 70 (89.7) | 568 (89.0) | 0.68 | 0.74 (0.36–1.51) | 1.08 (0.50–2.33) | NA | NA | |
| No rash | 10 (14.3) | 8 (10.3) | 70 (11.0) | NA | NA | NA | NA | NA | |
| Fever | 31 (44.3) | 36 (46.2) | 218 (34.2) | 0.04 | 1.53 (0.93–2.52) | 1.65 (1.03–2.65) | 1.63 (0.97–2.75) | 1.66 (1.03–2.66) | |
| No fever | 39 (55.7) | 42 (53.8) | 420 (65.8) | NA | NA | NA | NA | NA | |
*IUFD, intrauterine fetal death; NA, not applicable; OR, odds ratio. †Includes residents of Monte Plata Province. ‡No significant difference for other symptoms.