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. 2019 Jan 24;38:32. doi: 10.1186/s13046-018-1014-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — miR-133a-3p was negatively associated with the expression of RhoA in human CRC specimens. a-c Statistical analysis of the mRNA level of CXCR4, RhoA and miR-133a-3p in 22 pairs of human colon tissues and adjacent normal colon tissue. d The expression and location of CXCR4, RhoA and CD68 were analyzed by IHC assay in paired human CRC tissues and statistical analysis was performed. *P < 0.05 vs. normal colonic tissues. e The negative correlation between RhoA and miR-133a-3p expression was detected by Spearman’s correlation analysis in human CRC tissues