Table 4.
IgG Fc glycosylation patterns of preterm infants associated with (i) gender and clinical parameters defining (ii) cause of birth, (iii) bronchopulmonary dysplasia (BPD) or (iv) sepsis (early and late onset sepsis cases included) (mean ± SD, two-way ANOVA, multiple comparison within group to adjust for gestational age).
| <28 weeks | ≥28 weeks | |||
|---|---|---|---|---|
| (i) | Male (n = 26) | Female (n = 17) | Male (n = 18) | Female (n = 25) |
| Agalactosylation (%) | 15.0 ± 6.5 | 16.3 ± 6.1 | 12.4 ± 6.3 | 11.1 ± 4.2 |
| Galactosylation (%) | 85.0 ± 6.5 | 83.7 ± 6.1 | 87.6 ± 6.3 | 88.9 ± 4.2 |
| Terminal galactosylation (%) | 70.3 ± 3.7 | 69.6 ± 4.3 | 70.9 ± 5.5 | 70.1 ± 3.8 |
| Sialylation (%) | 14.7 ± 3.5 | 14.1 ± 3.2 | 16.7 ± 4.0 | 18.8 ± 4.7 |
| Bisection (%) | 8.8 ± 2.3 | 8.0 ± 1.8 | 11.1 ± 3.4 | 10.6 ± 2.2 |
| (ii) | Preterm labor or AIS (n= 31) | All other causes (n= 12) | Preterm labor or AIS (n= 27) | All other causes (n= 16) |
| Agalactosylation (%) | 15.2 ± 5.6 | 16.4 ± 8.0 | 11.3 ± 4.0 | 12.2 ± 6.9 |
| Galactosylation (%) | 84.8 ± 5.6 | 83.6 ± 8.0 | 88.7 ± 4.0 | 87.8 ± 6.9 |
| Terminal galactosylation (%) | 70.0 ± 3.4 | 70.0 ± 5.3 | 71.2 ± 3.7 | 69.3 ± 5.8 |
| Sialylation (%) | 14.8 ± 3.0 | 13.6 ± 4.0 | 17.5 ± 4.1 | 18.6 ± 5.1 |
| Bisection (%) | 8.3 ± 1.8 | 9.0 ± 2.8 | 9.8 ± 2.3 *** | 12.5 ± 2.7 |
| (iii) | BPD (n= 14) | No BPD (n= 29) | BPD (n= 7) | No BPD (n= 36) |
| Agalactosylation (%) | 17.0 ± 6.4 | 14.8 ± 6.2 | 16.9 ± 8.1* | 10.6 ± 3.8 |
| Galactosylation (%) | 83.0 ± 6.4 | 85.2 ± 6.2 | 83.1 ± 8.1* | 89.4 ± 3.8 |
| Terminal galactosylation (%) | 69.5 ± 4.2 | 70.3 ± 3.8 | 66.6 ± 5.4 | 71.2 ± 4.1 |
| Sialylation (%) | 13.5 ± 2.9 | 14.9 ± 3.5 | 16.5 ± 4.6 | 18.2 ± 4.5 |
| Bisection (%) | 8.4 ± 2.2 | 8.5 ± 2.1 | 10.9 ± 2.5 | 10.8 ± 2.8 |
| (iv) | Sepsis (n= 27) | No sepsis (n= 16) | Sepsis (n= 11) | No sepsis (n= 32) |
| Agalactosylation (%) | 16.6 ± 7.2 | 13.8 ± 3.9 | 14.8 ± 7.3 | 10.5 ± 3.8 |
| Galactosylation (%) | 83.4 ± 7.2 | 86.2 ± 3.9 | 85.2 ± 7.3 | 89.5 ± 3.8 |
| Terminal galactosylation (%) | 69.5 ± 4.6 | 70.8 ± 2.4 | 68.8 ± 5.5 | 71.1 ± 4.2 |
| Sialylation (%) | 13.9 ± 3.5 | 15.4 ± 3.0 | 16.4 ± 3.7 | 18.4 ± 4.7 |
| Bisection (%) | 8.7 ± 2.4 | 8.2 ± 1.6 | 12.1 ± 2.1 | 10.4 ± 2.8 |