Table 3.
Effects of PAFF on antioxidant defense systems and MDA content in liver tissues of GalN-treated mice
| Factors | Group 1 (Control) | Group 2 (GalN) | Group 3 (GalN + 50 mg/kg PAFF) | Group 4 (GalN + 100 mg/kg PAFF) | Group 5 (GalN + 200 mg/kg PAFF) | Group 6 (200 mg/kg PAFF) |
|---|---|---|---|---|---|---|
| GSH | 2.8 ± 0.3 | 1.1 ± 0.2*** | 1.3 ± 0.3*** | 1.8 ± 0.5***, ## | 2.5 ± 0.3### | 3.2 ± 0.3 |
| CAT | 61 ± 6.0 | 34 ± 7.2*** | 41 ± 8.9** | 52 ± 7.9# | 56 ± 12.0## | 66 ± 7.8 |
| SOD | 4.7 ± 0.4 | 1.2 ± 0.4*** | 1.7 ± 0.5*** | 2.8 ± 0.6***, ### | 3.9 ± 0.7### | 6.2 ± 0.5* |
| GPx MDA |
34.6 ± 6.6 1.2 ± 0.3 |
9.4 ± 3.1*** 5.6 ± 0.9*** |
14.7 ± 6.4*** 4.0 ± 1.1***, ## |
19.7 ± 6.4***, ##
2.7 ± 0.5**, ### |
23.0 ± 6.0*, ##
1.9 ± 0.6### |
35.7 ± 6.7 0.9 ± 0.3 |
Values are expressed as the mean ± SD for eight animals in each group (n = 5)
*p < 0.05, **p < 0.01, and ***p < 0.001, compared with group 1
#p < 0.05,##p < 0.01, and ###p < 0.001, compared with group 2
Units: GSH: mg/g tissue weight; CAT: U/mg tissue weight; SOD: U/mg protein; MDA: nmol/mg tissue weight; GPX: U/mg protein