Fig. 4.

The receiver operating characteristic (ROC) curve showing cut off value, sensitivity, specificity and area under curve for a ROC of tissue miRNA-21 in BC group relative to the BBL group (cut off value = 0.87, sensitivity = 100%, specificity = 100%, and area under curve = 1). Plasma miRNA-21 in breast cancer (BC) group relative to the healthy control (HC) group (cut off value = 1.2, sensitivity = 90%, specificity = 86%, and area under curve = 0.93), and in BC group relative to the benign breast lesion (BBL) group (cut off value = 1.7, sensitivity = 93.3%, specificity = 83.3%, and area under curve = 0.94). c serum CA 15-3 in breast cancer with control (cut off value = 32.5, sensitivity = 70%, specificity = 56%, and area under curve = 0.69) and benign breast lesion groups (cut off value = 33.5, sensitivity = 60%, specificity = 50%, and area under curve = 0.639)