Table 3.
Genotype and allelic frequency distribution of GEMIN4 C/T (rs3744741), GEMIN4 T/C (rs7813) and GEMIN4 G/C (rs910925) gene polymorphism in RCC patient and healthy controls
| Genetic model | Genotypes | Controls n = 225 n (%) |
Patients n = 100 n (%) |
#p value | ORa (95%CI) |
|---|---|---|---|---|---|
| GEMIN4 C/T rs3744741 | |||||
| Additive | CC | 123 (54.7) | 51 (51.0) | Ref | Ref |
| CT | 86 (38.2) | 36 (36.0) | 0.582 | 1.18 (0.65–2.14) | |
| TT | 16 (7.1) | 13 (13.0) | 0.106 | 2.16 (0.85–5.53) | |
| Dominant | CC | 123 (54.7) | 51 (51.0) | Ref | Ref |
| CT + TT | 102 (45.3) | 49 (49.0) | 0.339 | 1.31 (0.75–2.28) | |
| Multiple | C | 332 (73.8) | 138 (69.0) | Ref | Ref |
| T | 118 (26.2) | 62 (31.0) | 0.209 | 1.26 (0.88–1.82) | |
| GEMIN4 T/C rs7813 | |||||
| Additive | TT | 115 (51.1) | 39 (39.0) | Ref | Ref |
| TC | 89 (39.6) | 41 (41.0) | 0.918 | 1.03 (0.56–1.90) | |
| CC | 21 (9.3) | 20 (20.0) | 0.005 | 3.37 (1.44–7.89) | |
| Dominant | TT | 115 (51.1) | 39 (39.0) | Ref | Ref |
| TC + CC | 110 (48.9) | 61 (61.0) | 0.021 | 1.94 (1.11–3.41) | |
| Multiple | T | 319 (70.9) | 119 (59.5) | Ref | Ref |
| C | 131 (29.1) | 81 (40.5) | 0.004 | 1.66 (1.17–2.35) | |
| GEMIN4 G/C rs910925 | |||||
| Additive | GG | 100 (44.4) | 37 (37.0) | Ref | Ref |
| GC | 93 (41.3) | 35 (35.0) | 0.693 | 0.88 (0.47–1.65) | |
| CC | 32 (14.2) | 28 (28.0) | 0.024 | 2.37 (1.12–4.99) | |
| Dominant | GG | 100 (44.4) | 37 (37.0) | Ref | Ref |
| GC + CC | 125 (55.5) | 63 (63.0) | 0.062 | 1.72 (0.97–3.04) | |
| Multiple | G | 293 (65.1) | 109 (54.5) | Ref | Ref |
| C | 157 (34.9) | 91 (45.5) | 0.010 | 1.56 (1.11–2.19) | |
The statistically significant values are shown in bold
OR odds ratio, CI confidence interval
aOR (95%CI); Age, gender and smoking adjusted odds ratio and 95% confidence interval
#Student’s t test was used to determine p value