Table 4.
Association of GEMIN4 C/T (rs3744741), GEMIN4 T/C (rs7813) and GEMIN4 G/C (rs910925) gene variants with smoking habit in RCC susceptibility
| Genotype | Patients Non smokers n = 32; n (%) |
Patients Smoker n = 61; n (%) |
p value | ORa (95% CI) |
|---|---|---|---|---|
| GEMIN4 C/T rs3744741 | ||||
| CC | 16 (50.0) | 30 (49.2) | Ref | Ref |
| CT | 10 (31.2) | 24 (39.3) | 0.721 | 0.80 (0.23–2.71) |
| TT | 6 (18.8) | 7 (11.5) | 0.129 | 0.31 (0.07–1.41) |
| GEMIN4 T/C rs7813 | ||||
| TT | 11 (45.8) | 35 (50.7) | Ref | Ref |
| TC | 8 (33.4) | 26 (37.7) | 0.227 | 2.09 (0.63–6.91) |
| CC | 5 (20.8) | 8 (11.6) | 0.034 | 3.51 (1.16–4.29) |
| GEMIN4 G/C rs910925 | ||||
| GG | 9 (37.5) | 26 (37.7) | Ref | Ref |
| GC | 7 (29.2) | 25 (36.2) | 0.507 | 1.53 (0.43–5.42) |
| CC | 8 (33.3) | 18 (26.1) | 0.587 | 1.46 (0.37–5.85) |
Statistically significant values are shown in bold
OR odds ratio, CI confidence interval
aOR (95%CI) Age, gender adjusted odds ratio and 95% confidence interval