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. 2019 Jan 17;9:3307. doi: 10.3389/fmicb.2018.03307

FIGURE 2.

FIGURE 2

C57BL/6J and C57BL/6NJ mice exhibit differential susceptibility to H7N9 and highly pathogenic H5N1 influenza virus disease. Groups of five or six C57BL/6J or C57BL/6NJ mice were intranasally infected with serial dilutions of (A) influenza A/Anhui/1/2013 (H7N9; ‘AH1’), or (B) influenza A/Vietnam/1203/2004 (H5N1; ‘VN1203’), and body weight ratios and survival were monitored for 12 days. Body weight ratios and significance are shown as in Figure 1B. For survival curves that significantly differ between C57BL/6J and C57BL/6NJ mice, p-values are given on the survival curve panel. Median lethal doses were calculated for each virus in each mouse strain by using the Reed and Muench method (Reed and Muench, 1938), and are shown at the right of each panel. NS, not significant; d, day.