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MCR chemistry and its applications. A) The concept of MCR chemistry involves the convergent assembly of complex products by at least 3 but currently up to 11 starting materials. B) Different natural products, marketed drugs, and clinical candidates that can be efficiently synthesized by the Ugi reaction and other MCRs. C) A chiral R-Ugi product crystallized with the oncogenic MDM2 protein (PDB ID 3TU1).
