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. 2017 Feb 16;4(4):000463. doi: 10.12890/2017_000463

Table 1.

European Society for Immunodeficiencies (ESID) 2014 criteria for common variable immunodeficiency (CVID)[3]

At least one of the following:

  • Increased susceptibility to infection

  • Autoimmune manifestations

  • Granulomatous disease

  • Unexplained polyclonal lymphoproliferation

  • Affected family member with antibody deficiency

AND

  • A marked decrease in IgG and marked decrease in IgA with or without low IgM levels (measured at least twice; <2 SD of the normal levels for the patient’s age)

AND
Either:

  • Poor antibody response to vaccines (and/or absent isohaemagglutinins)

Or:

  • Low switched memory B cells (<70% of age-related normal value)

AND

  • Age ≥4 years

AND
No evidence of T cell deficiency defined as two of the following:

  • CD4 count (cells/μl): 2–6 years <00, 6–12 years <250, >12 years <200

  • % Naive CD4: 2–6 years <25%, 6–16 years <20%, >16 years <10%

  • T cell proliferation absent