Figure 4.

The effects of NMDA receptor antagonists and agonists on transepithelial electrical resistance in the brain microvessel endothelial cells. 1: anti-NR2 antibody (100 μl, 10 μg/ml), 2: glutamate (5 mM), 3: ifenprodil (10 μg/ml), 4: memantine (10 μg/ml), 5: ifenprodil (10 μg/ml) + anti-NR2 antibody (100 μl, 10 μg/ml), 6: memantine (10 μg/ml) + anti-NR2 antibody (100 μl, 10 μg/ml). After culture for 12 h, the TEER was measured. Results are averages of 3 independent experiments. Data are represented as mean ±SEM.