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. 2019 Jan 22;7:e6267. doi: 10.7717/peerj.6267

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©2019 Pang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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(A) Bar charts showing the number of differentially expressed circRNAs, mRNAs, miRNAs, respectively. Red bars, up-regulated RNAs; green bars, down-regulated RNAs. (B) Heatmap of differentially expressed circRNAs. (C) Heatmap of differentially expressed miRNAs. (D) Heatmap of differentially expressed mRNAs. Color from green to red; the deeper the color, the higher the expression. (E) Volcano plot of differentially expressed mRNAs. Vertical lines correspond to 2-fold changes in up-regulation and down-regulation. Horizontal line represents p value 0.05. Red points refer to up-regulated mRNAs; Green points refer to down-regulated mRNAs; Blue points refer to mRNAs with no significant difference.