Table 2.
Nondiabetic Controls |
T1D |
||||||
---|---|---|---|---|---|---|---|
Younger | Older | Euglycemia | Hyperglycemia | Normofiltration | Hyperfiltration | T2D Overweight | |
Cohorts | |||||||
Ref. no. | 81 | 99 | 81 | 81 | 81 | 81 | 89 |
Size, n | 25 | 26 | N/A/73 | N/A/73 | 35/73 | 38/73 | 52 |
Cohort characteristics | |||||||
Age, yr | 27 ± 6 | 50 ± 13 | / | / | 24 ± 5 | 23 ± 4 | 63 ± 7 |
Female, % | 56 | 50 | / | / | 40 | 55 | 25 |
Renal hemodynamic parameters | |||||||
GFR | 117 ± 11 | 95 ± 24 | 144 ± 32.9 | 156 ± 30.7 | 116 ± 10 | 177 ± 35 | 82 ± 4 |
ERPF, ml·min−1·1.73 m−2 | 628 ± 162 | 497 ± 172 | 810 ± 269 | 831 ± 236 | 642 ± 93 | 970 ± 268 | 345 ± 18 |
RBF, ml·min−1·1.73 m−2 | 1,039 ± 287 | 810 ± 279 | 1,299 ± 439 | 1,309 ± 399 | 1,031 ± 171 | 1,552 ± 466 | 605 ± 32 |
RVR, mmHg/min | 0.081 ± 0.019 | 0.068 ± 0.02 | 0.067 ± 0.017 | 0.080 ± 0.014 | 0.057 ± 0.017 | 0.184 ± 0.012 | |
FF | 0.19 ± 0.04 | 0.20 ± 0.06 | 0.18 ± 0.04 | 0.19 ± 0.05 | 0.18 ± 0.03 | 0.18 ± 0.06 | 0.24 ± 0.01 |
Filtration pressure, mmHg | 22.4 ± 2.2 | 28 ± 6 | 30 ± 7 | 22 ± 2 | 32 ± 5 | ||
RA, dyn·s−1·cm−5 | 1,676 ± 706 | 3,778 ± 2856 | 1,473 ± 798 | 1,325 ± 825 | 2,065 ± 597 | 914 ± 494 | 6,176 ± 607 |
RE, dyn·s−1·cm−5 | 2,043 ± 463 | 1,596 ± 1,195 | 2,021 ± 590 | 2,205 ± 716 | 1,993 ± 367 | 2,047 ± 747 | 3,957 ± 105 |
PGLO, mmHg | 60 ± 3 | 52 ± 8 | 61 ± 8 | 62 ± 8 | 55 ± 3 | 66 ± 6 | 60 ± 1 |
Oncotic pressure, mmHg | 27 ± 3 | 23 ± 3 | 22 ± 3 | 22 ± 3 | 24 ± 3 |
Data are means ± SD; n, no. of subjects. ERPF, effective renal plasma flow; RVR, renal vascular resistance.