Figure 1.

A. Missense z-scores from EXAC of genes identified in DCM. Z-scores for genes with deleterious variants in DCM patients and population frequency <1% (open circles, n = 68) or 0.1% (filled squares, n = 51) were obtained from ExAC. Scores were binned in 0.5 increments and plotted as number of genes in bin / total genes. Dotted vertical line is mean z-score of 1.3. B. Ratio of variant frequency in African / African American populations versus variant frequency across all populations. Data derived from ExAC, August, 2016 release. This Figure is reproduced in color in the online version of Medical Mycology.