Bile acids that changed following clindamycin treatment and correlated with
C difficile TVC (VA= saline-treated cultures, dashed line;
VB= FMT-treated cultures, solid line). (A) taurocholic acid (TCA),
(B) cholic acid (CA), (C) deoxycholic acid (DCA),
and (D) lithocholic acid (LCA). The shaded grey box indicates the
clindamycin-dosing period, while the vertical dotted line indicates the day of
FMT or saline dosing. Steady state cultures were compared to clindamycin-treated
cultures using SANTA analysis with Benjamini-Hochberg FDR.