Table 6.
Estimated allelic effects in the mean regression and quantile regression at quantile levels of 0.15, 0.25, 0.5, 0.75, and 0.85. The quantile coefficients are estimated using KS, SICO and IPW approaches.
| SNPs | mean
|
MethodS | τ = 0.15
|
τ = 0.25
|
τ = 0.5
|
τ = 0.75
|
τ = 0.85
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Est. | P-value | Est. | P-value | Est. | P-value | Est. | P-value | Est. | P-value | Est. | P-value | ||
| rs2289276 | 0.6 | 0.593 | KS | 1.6 | 0.437 | 2.0 | 0.175 | −0.2 | 0.900 | 0.5 | 0.797 | 1.1 | 0.496 |
| SICO(m=10) | 1.1 | 0.157 | 1.8 | 0.007 | 0.0 | 0.999 | −0.5 | 0.449 | 0.0 | 0.980 | |||
| IPW | 2.0 | 0.257 | 1.5 | 0.292 | −0.5 | 0.680 | −0.3 | 0.877 | 0.3 | 0.865 | |||
|
| |||||||||||||
| rs1898671 | 0.2 | 0.920 | KS | −2.3 | 0.235 | −1.1 | 0.597 | −1.2 | 0.585 | 0.7 | 0.740 | 1.6 | 0.391 |
| SICO(m=10) | −2.7 | 0.000 | −2.2 | 0.003 | −1.8 | 0.010 | −0.4 | 0.550 | 1.0 | 0.161 | |||
| IPW | −3.1 | 0.176 | −2.1 | 0.307 | −0.7 | 0.776 | 0.6 | 0.800 | 1.5 | 0.473 | |||
|
| |||||||||||||
| rs11466741 | −0.6 | 0.585 | KS | 0.1 | 0.950 | 2.4 | 0.144 | 0.2 | 0.884 | 1.7 | 0.318 | 1.2 | 0.373 |
| SICO(m=10) | 0.8 | 0.235 | 2.2 | 0.000 | 0.6 | 0.277 | 1.5 | 0.010 | 1.1 | 0.033 | |||
| IPW | 2.0 | 0.269 | 2.6 | 0.084 | 0.1 | 0.973 | 2.0 | 0.242 | 1.1 | 0.386 | |||
|
| |||||||||||||
| rs11466743 | −8.1 | 0.009 | KS | −17.4 | 0.066 | −3.4 | 0.775 | −1.4 | 0.824 | −6.7 | 0.155 | −7.3 | 0.313 |
| SICO(m=10) | −17.2 | 0.003 | −6.7 | 0.015 | −1.9 | 0.307 | −7.5 | 0.000 | −6.9 | 0.001 | |||
| IPW | −18.4 | 0.103 | −3.9 | 0.733 | −2.5 | 0.638 | −6.8 | 0.216 | −7.4 | 0.319 | |||
|
| |||||||||||||
| rs2289277 | 0.6 | 0.544 | KS | 2.5 | 0.198 | 2.5 | 0.039 | −0.3 | 0.862 | 0.7 | 0.545 | −0.2 | 0.891 |
| SICO(m=10) | 3.0 | 0.000 | 2.6 | 0.000 | 0.2 | 0.797 | 0.5 | 0.309 | −0.1 | 0.886 | |||
| IPW | 3.4 | 0.105 | 2.1 | 0.075 | −0.5 | 0.800 | 0.2 | 0.872 | −0.5 | 0.637 | |||
|
| |||||||||||||
| rs2289278 | 3.5 | 0.041 | KS | 0.3 | 0.888 | −1.5 | 0.610 | 6.0 | 0.078 | 2.1 | 0.349 | 0.1 | 0.951 |
| SICO(m=10) | 0.5 | 0.691 | −1.9 | 0.140 | 5.8 | 0.000 | 1.4 | 0.125 | −0.8 | 0.336 | |||
| IPW | −1.2 | 0.641 | −1.6 | 0.633 | 6.0 | 0.028 | 1.0 | 0.631 | −0.6 | 0.780 | |||
|
| |||||||||||||
| rs11241090 | −4.8 | 0.042 | KS | −2.1 | 0.816 | 2.2 | 0.699 | −1.4 | 0.658 | −6.3 | 0.061 | −7.1 | 0.147 |
| SICO(m=10) | −3.7 | 0.189 | −0.3 | 0.900 | −0.7 | 0.671 | −5.9 | 0.000 | −2.5 | 0.145 | |||
| IPW | −3.5 | 0.678 | 2.0 | 0.696 | −2.5 | 0.486 | −7.0 | 0.099 | −7.2 | 0.222 | |||
|
| |||||||||||||
| rs10035870 | −1.1 | 0.659 | KS | −1.2 | 0.706 | 0.2 | 0.971 | 3.2 | 0.545 | 6.4 | 0.271 | 7.4 | 0.108 |
| SICO(m=10) | 0.9 | 0.472 | 1.5 | 0.234 | 2.8 | 0.063 | 5.6 | 0.000 | 7.6 | 0.000 | |||
| IPW | −2.2 | 0.606 | 0.2 | 0.966 | 2.2 | 0.688 | 5.7 | 0.319 | 7.3 | 0.150 | |||
|
| |||||||||||||
| rs11466749 | 1.4 | 0.368 | KS | 2.5 | 0.226 | 2.3 | 0.246 | −0.7 | 0.809 | −1.7 | 0.438 | −2.4 | 0.210 |
| SICO(m=10) | 2.3 | 0.010 | 1.5 | 0.114 | −0.8 | 0.455 | −1.3 | 0.151 | −2.5 | 0.003 | |||
| IPW | 2.5 | 0.345 | 2.0 | 0.304 | −0.9 | 0.775 | −1.8 | 0.451 | −3.0 | 0.197 | |||
|
| |||||||||||||
| rs11466750 | −1.0 | 0.457 | KS | 0.9 | 0.673 | 0.6 | 0.733 | 0.4 | 0.853 | −2.1 | 0.313 | −2.4 | 0.218 |
| SICO(m=10) | 0.5 | 0.424 | 0.5 | 0.510 | 0.2 | 0.801 | −2.3 | 0.008 | −1.9 | 0.003 | |||
| IPW | 0.4 | 0.827 | 1.8 | 0.323 | −1.1 | 0.592 | −2.5 | 0.204 | −1.6 | 0.406 | |||