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. 2019 Jan 25;14(1):e0210198. doi: 10.1371/journal.pone.0210198

Table 1. Physiological parameters (protocol 1).

    Bederson score Weight(gram) Temperature(°C)
Day of injection PBS MNCs RACs PBS MNCs RACs PBS MNCs RACs

Day 1
Pre-operation 15±0 15±0 15±0 23.95±1.60 23.53±1.58 24.45±1.52 31.52±8.46 30.27±9.07 32.70±7.45
Injection 11.9
±2.0
11.5
±2.5
12.8
±1.8
27.82±8.29 28.15±8.37 26.68±7.14 31.75±7.27 31.24±7.79 33.77±6.17
Sacrificed 14.3±1.1 14.3±0.9 14.8±0.4 28.20±7.48 29.62±6.82 28.28±6.08      

Day 3
Pre-operation 15±0 15±0 15±0 24.54±1.72 24.84±1.12 24.63±0.99 23.38±1.74 23.50±1.39 23.03±1.16
Injection 13
±1.2
12.3
±1.9
13.4
±0.8
37.83±0.69 37.76±0.40 37.80±0.62 24.74±1.56 25.43±0.96 23.46±2.84
Sacrificed 14.0
±1.4
14.1
±1.1
13.4
±1.1
37.21±0.51 37.66±0.42 37.60±0.36      

Day 5
Pre-operation 15±0 15±0 15±0 24.32±1.54 25.28±1.56 22.82±0.84 24.76±1.20 25.32±1.75 23.42±0.76
Injection 14±0 13.6
±0.5
13.8
±0.4
37.74±0.18 37.48±0.59 37.32±0.78 26.30±1.72 25.82±2.04 25.14±1.69
Sacrificed 14.4
±0.9
15±0 14.6
±0.5
37.42±0.55 37.72±0.36 37.60±0.37      

Day 7
Pre-operation 15±0 15±0 15±0 25.06±1.61 25.22±1.37 22.82±0.80 23.74±1.74 24.00±1.42 22.78±0.67
Injection 11.0
±2.4
11.4
±2.1
12.0
±0.1
37.48±0.68 38.42±0.54 38.08±0.41 24.26±2.09 24.26±1.89 23.78±1.05
Sacrificed 14.8
±0.4
14.2
±0.4
14.6
±0.6
36.78±0.69 38.00±0.37 37.16±0.54      

There was no significant difference between animals injected with PBS and MNCs or RACs, injected on either day 1 (PBS: n = 13, MNCs: n = 12, RACs: n = 13), day 3 (PBS: n = 8, MNCs: n = 8, RACs: n = 7), day 5 (each group: n = 5), or day 7 (each group: n = 5) in terms of Bederson score at the late phase, weight at any time, and temperature at any time (pre-operation, injection, and scarification).