Table 1. Mouse body weights along with the structural geometry, histomorphometry, and mechanical properties of the tibia in response to physical activity and genotype.
Mean ± stdev (n = 10).
| PPRfl/fl | PPRcKO | Two-Way ANOVA Results | |||||
|---|---|---|---|---|---|---|---|
| Sedentary mean (std) |
Exercise mean (std) |
Sedentary mean (std) |
Exercise mean (std) |
Genotype (p-value) |
Activity (p-value) |
Interaction (p-value) |
|
| Body Weight (g) | 26.2 (2.4) | 24.8 (1.5) ‡ | 20.0 (2.7) ‡ | 17.3 (1.9) *,# | <0.001 | 0.019 | 0.692 |
| Geometric Properties | |||||||
| Tibia Length (mm) | 18.29 (0.54) | 18.11 (0.24) | 17.55 (0.81) ‡ | 16.92 (0.60) * | 0.002 | 0.182 | 0.371 |
| Cortical Area (mm2) | 0.75 (0.1) | 0.71 (0.07) | 0.60 (0.10) ‡ | 0.58 (0.07) * | <0.001 | 0.363 | 0.808 |
| MOIA/P (mm4) | 0.079 (0.020) | 0.079 (0.011) | 0.064 (0.017) ‡ | 0.059 (0.012) * | 0.005 | 0.683 | 0.692 |
| Distance to Neutral Axis (mm) | 0.625 (0.039) | 0.617 (0.035) | 0.595 (0.033) | 0.596 (0.038) | 0.089 | 0.884 | 0.890 |
| Histomorphometry | |||||||
| Endosteal MS/BS (μm/μm) | 0.696 (0.182) | 0.837 (0.119) | 0.823 (0.220) | 0.774 (0.222) | 0.628 | 0.499 | 0.160 |
| Endosteal MAR (μm/week) | 19.4 (8.7) | 16.6 (4.6) | 18.1 (9.4) | 11.4 (7.2) | 0.232 | 0.083 | 0.480 |
| Endosteal BFR (μm/μm/week) | 14.5 (8.0) | 13.8 (4.4) | 16.5 (10.4) | 9.7 (6.1) | 0.675 | 0.176 | 0.261 |
| Periosteal MS/BS (μm/μm) | 0.371 (0.096) | 0.360 (0.100) | 0.336 (0.080) | 0.372 (0.114) | 0.742 | 0.732 | 0.508 |
| Periosteal MAR (μm/week) | 4.7 (4.4) | 5.8 (4.8) | 6.8 (6.0) | 4.9 (4.8) | 0.754 | 0.793 | 0.403 |
| Periosteal BFR (μm/μm/week) | 1.96 (1.8) | 2.1 (2.0) | 2.2 (1.9) | 1.7 (1.7) | 0.921 | 0.780 | 0.650 |
‡ p<0.05 compared to sedentary-PPRfl/fl
* p<0.05 compared to exercised-PPRfl/fl
# p<0.05 compared to sedentary-PPRcKO