Table 2. Structural-level properties of the tibia are influenced by PPR expression along the osteoblast lineage.
Mean +/- stdev (n = 10).
| PPRfl/fl | PPRcKO | Two-Way ANOVA Results | |||||
|---|---|---|---|---|---|---|---|
| Sedentary mean (std) |
Exercise mean (std) |
Sedentary mean (std) |
Exercise mean (std) |
Genotype (p-value) |
Activity (p-value) |
Interaction (p-value) |
|
| Yield Load (N) | 19.1 (4.5) | 21.1 (2.6) | 12.3 (2.1) ‡‡ | 11.4 (2.3) ** | <0.001 | 0.600 | 0.174 |
| Yield Displacement (μm) | 297.2 (84.4) | 250.1 (50.5) | 231.5 (45.1) | 217.5 (40.2) | 0.016 | 0.126 | 0.402 |
| Ultimate Load (N) | 21.2 (3.7) | 22.5 (2.3) | 14.1 (1.8) ‡‡ | 13.6 (1.8) ** | <0.001 | 0.649 | 0.322 |
| Ultimate Displacement (μm) | 372.8 (98.7) | 293.1 (59.4) | 381.2 (96.5) | 390.5 (61.9) ** | 0.056 | 0.215 | 0.112 |
| Stiffness (N/mm) | 82.47 (28.6) | 109.5 (20.1) ‡ | 61.2 (9.1) | 60.3 (9.9) * | <0.001 | 0.045 | 0.030 |
| Pre-Yield Work (mJ) | 2.96 (1.08) | 2.57 (0.59) | 1.62 (0.52) ‡‡ | 1.43 (0.48) ** | <0.001 | 0.352 | 0.863 |
‡ p<0.05 compared to sedentary-PPRfl/fl
‡‡ p< 0.01 compared to sedentary-PPRfl/fl
* p< 0.05 compared to exercise-PPRfl/fl
** p< 0.01 compared to exercise-PPRfl/fl