Table 3. The absence of PPR expression along the osteoblast lineage reduces the impact of exercise on the tissue-level properties of the tibia.
Mean ± stdev (n = 10).
| PPRfl/fl | PPRcKO | Two-Way ANOVA Results | |||||
|---|---|---|---|---|---|---|---|
| Sedentary mean (std) |
Exercise mean (std) |
Sedentary mean (std) |
Exercise mean (std) |
Genotype (p-value) |
Activity (p-value) |
Interaction (p-value) |
|
| Yield Stress (MPa) | 187.4 (41.7) | 234.7 (42.5) | 155.3 (54.4) | 161.8 (41.6) ** | 0.002 | 0.088 | 0.193 |
| Yield Strain (με) | 25,540 (6,606) | 21,545 (5,238) | 20,667 (3,837) | 18,629 (3,185) | 0.023 | 0.074 | 0.554 |
| Ultimate Stress (MPa) | 209.7 (39.2) | 249.9 (41.4) | 176.5 (56.2) | 192.4 (43.5) * | 0.005 | 0.077 | 0.437 |
| Ultimate Strain (με) | 31,867 (6,339) | 25,260 (6,227) | 33,784 (6,507) | 33,747 (7,202) * | 0.022 | 0.136 | 0.140 |
| Modulus (GPa) | 9.1 (2.2) | 14.0 (2.4) ‡ | 9.0 (4.3) | 10.1 (2.9) * | 0.055 | 0.008 | 0.076 |
| Pre-Yield Toughness (MPa) | 2.50 (0.96) | 2.38 (1.16) | 1.77 (0.63) ‡ | 1.72 (0.58) * | 0.004 | 0.888 | 0.754 |
‡ p< 0.05 compared to sedentary-PPRfl/fl
* p<0.05 compared to exercise-PPRfl/fl
** p<0.01 compared to exercise-PPRfl/fl