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. 2019 Jan 25;14(1):e0208681. doi: 10.1371/journal.pone.0208681

Fig 1. Behavioral scoring and survival Kaplan-Meyers curve in mice after lethal dose of LPS.

Fig 1

(A) Mean behavioral scores in mice every 30 mins, using scoring criteria of Schrum et al [24] in LPS-CONT, pGz pre-treatment (pGz-LPS) and pGz post-treatment (LPS-pGz). Scoring was begun 30 min after LPS injection and continued until death or survival for up to 48 hrs. (B) Survival in mice exposed to a lethal dose of LPS over the initial 48 hrs. Fifty percent survival in LPS treated mice was reached at 20 hrs. after LPS in control animals (LPS-CONT), in contrast all LNAME pretreated animals reached 50% survival at 12 hrs. 80% of LPS-pGz and 60% of pGz-LPS animals survived beyond 48 hrs. Data are mean ± SEM (†p<0.01 pGz-LPS or LPs-pGz vs. LPS-CONT ǂ p< 0.01 LPS-pGz vs. pGz-LPS, * p< 0.01 L-NAME-LPS-pGz or L-NAME-pGz-LPS or L-NAME-LPS-CONT vs LPS-CONT).