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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Trends Parasitol. 2018 Mar 9;34(5):420–429. doi: 10.1016/j.pt.2018.02.006

Table 2.

Plasmodium vivax invasion ligands and their host receptor specificities.

P. vivax ligands PlasmoD B ID Localization Binding to reticulocytes/erythrocytes Host Receptor specificities based on enzyme treatment Interaction Partner: Host Receptor/Parasite ligand References
DBP1 PvX_110810 Microneme Erythrocytes, higher affinity for reticulocytes Sensitive to chymotrypsin Duffy blood group antigen [37, 39, 41]
DBP2/EBP PVP01_0102300 Unknown Reticulocytes Unknown Unknown [50]
RBP1a1 PVX_098585 Microneme Reticulocytes or all aged erythrocytes? Sensitive to trypsin and chymotrypsin Unknown [47, 55, 57]
RBP1b1 PVX_098582 Microneme Reticulocytes or all aged erythrocytes? Partially sensitive to trypsin and chymotrypsin Unknown [47, 57]
RBP2a PVX_121920 Unknown Erythrocytes Sensitive to trypsin Unknown [56, 57]
RBP2b PVX_094255 Unknown Reticulocytes Sensitive to trypsin and chymotrypsin Transferri n receptor [57, 58]
RBP2c PVX_090325 Merozoite apical end Reticulocytes Resistant to trypsin, chymotrypsin and neuraminidase Unknown [55]
RBP2-P2 PVX_101590 Unknown Erythrocytes Unknown Unknown [57]
GAMA PVX_088910 Microneme Reticulocyte Sensitive to chymotrypsin, partially resistant to trypsin Unknown [59, 60]
PvTRAg PVX_090265 Unknown Erythrocytes Resistant to trypsin, chymotrypsin and neuraminidase Unknown [62]
PvTRAg26.3 PVX_112660 Unknown Erythrocytes Resistant to trypsin, chymotrypsin and neuraminidase Unknown [61]
PvTRA g33.5 PVX_121897 Unknown Erythrocytes Resistant to trypsin, chymotrypsin and neuraminidase Unknown [62]
PvTRA g34 PVX_112685 Unknown Erythrocytes Resistant to trypsin, chymotrypsin and neuraminidase Unknown [61]
PvTRA g35.2 PVX_109280 Unknown Erythrocytes Resistant to trypsin, chymotrypsin and neuraminidase Unknown [62]
PvTRA g36 PVX_112675 Unknown Erythrocytes Sensitive to chymotrypsin Band 3 [61]
PvTRA G36.6 PVX_112690 Merozoite apical end Erythrocytes Resistant to trypsin, chymotrypsin and neuraminidase ETRAMP [61, 63]
PvTRA g38 PVX_088820 Unknown Erythrocytes Partially sensitive to chymotrypsin Band 3, Basigin [61, 62, 64, 66]
PvTRA g69.4 PVX_115465 Unknown Erythrocytes Resistant to trypsin, chymotrypsin and neuraminidase Unknown [62]
PvATR Ag74 PVX_101510 Unknown Erythrocytes Partially sensitive to chymotrypsin Band 3 [61, 62]
1

The specificities of RBP1a and RB1b for reticulocytes are controversial [47,55,57].