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. Author manuscript; available in PMC: 2019 May 8.
Published in final edited form as: J Am Coll Cardiol. 2018 May 8;71(18):1999–2010. doi: 10.1016/j.jacc.2018.02.066

Figure 4. The beneficial effects of trehalose on cardiac apoptosis and fibrosis in response to LAD ligation are attenuated in beclin 1+/− mice.

Figure 4

A–F. WT and beclin 1+/− mice with LAD ligation received placebo (CT) or trehalose (TRE). After 4 weeks, infarct size was measured (A). Representative pictures of Masson’s trichrome staining of the whole left ventricular transverse section are also shown (B). Scale bar: 1 mm. Apoptosis was evaluated by quantification of TUNEL positive cells (C–D). Data are expressed as fold vs. CT. N=4–7 per group. The percentage of cardiac fibrosis was also quantified (E) and representative pictures of Masson’s trichrome staining are shown (F). N=4 per group. **p<0.01. Scale bar: 50 μm.