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Vasomotor effect of cumulative dose-dependent administration of: PACAP1-38 (a); PACAP1-27 (b); and VIP (c) in carotid artery; and PACAP1-38 (d); PACAP1-27 (e); and VIP (f) in femoral artery of wild type (WT) mice and PACAP knockout (KO) mice. Arterial relaxation is marked as negative change in force. Data are expressed as means ± SEM (n = 6/group). *p < 0.05 WT vs. KO mice; #p < 0.05 WT mice vs. baseline; Δp < 0.05 KO mice vs. baseline.
