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Vasomotor effect of cumulative dose-dependent administration of: PACAP1-38 (a), PACAP1-27 (b) and VIP (c) in carotid artery; and PACAP1-38 (d), PACAP1-27 (e) and VIP (f) in femoral artery of wild-type (WT) and PACAP knockout (KO) mice in the presence of VPAC1R antagonist VIP6-28. Arterial relaxation is marked as negative change in force. Data are expressed as means ± SEM (n = 3-6/group). *p < 0.05 WT vs. WT+VIP6-28 mice; #p < 0.05 KO vs. KO+VIP6-28 mice.
