Figure 5.

a) Graphical representation of self-oxidation and photobleaching of BPD and its lipidated derivatives by the production of reactive molecular species (RMS) following photoirradiation using 690 nm laser light. ‘R’ indicates either a hydroxyl group of the carboxylate in native BPD, or the lipids conjugated in the lipidated variants. Self-oxidation leads to molecular fragmentation of the PS molecule, resulting in permanent photobleaching. b) Rates of photobleaching of BPD or its lipidated derivatives free in DMSO or entrapped in nanolipid formulations in PBS. (Statistical analysis performed by One-way ANOVA with a Tukey Post-Test. Values are mean ± S.E.M., n=4)