Table 3.
A summary of IC50 values (μM) of six model compounds obtained from the chip platform with the four HCI assays.
| Compound | TMRM | Hoechst | mBCl | Calcein AM | 2D (literature review) | LD50 mg/kg (rat oral) |
|---|---|---|---|---|---|---|
| Acetaminophen | >2100 | >2100 | >2100 | >2100 | 29,755±1775 | 1944 |
| Lovastatin | 152± 6.7 | 188± 17.7 | 195± 5.0 | 150± 0.0 | 20 ± 3.7 | 5000 |
| Rotenone | 0.6± 0.3 | 3.0 ± 0.0 | 1.7± 0.7 | 8.0± 6.0 | 1.7± 1.2 | 30 |
| Tamoxifen | 50± 0.5 | 102± 6.2 | 83± 18.5 | 57± 4.3 | 45 | 4100 |
| Menadione | 11.5± 2.5 | 20± 1.0 | 15± 2.3 | 11± 3.8 | 13.5± 3.6 | 500 (mice oral) |
| Sodium citrate | >1400 | >1400 | >1400 | >1400 | >1400 | 6730 |