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Enzymes catalyzing the conversion steps are listed numerically. Of note, serine palmitoyltransferase (SPT) catalyzes the condensation reaction between serine and palmitoyl-CoA, the rate limiting induction step in sphingolipid biosynthesis. Sphingosine phosphate lyase (SPL) catalyzes the irreversible cleavage of sphingosine-1-phosphate (S1P), the final and essential step in sphingolipid catabolism.
