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. 2019 Jan 25;10(2):67. doi: 10.1038/s41419-019-1338-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Scheme of the experiment in (b) and (c). To label LPSNs, the retrograde tracer, Fluoro-Ruby (FR), was injected into T12. Immunohistochemistry for Sema3A was then performed. b Transverse cervical sections (C4-C7) showing Sema3A and FR-labeled LPSNs in sham (upper) and injured (lower) mice. White arrows indicate LPSNs expressing Sema3A. White arrowheads indicate LPSNs not expressing Sema3A. Scale bar: 200 μm. c Quantification of the ratio of LPSNs expressing Sema3A in cervical enlargement. The ratio was decreased after SCI. d Scheme of the experiment in (e) and (f). To label short propriospinal neurons (SPSNs), FR was injected into C7 level spinal cord. e Transverse cervical sections (C4-C7) showing Sema3A and FR-labeled SPSNs in sham (upper) and injured (lower) mice. Scale bar: 200 μm. f Quantification of the ratio of SPSN expressing Sema3A in cervical enlargement. Data are presented as mean ± SEM. n = 7–8 (c), 6–7 (f), *p < 0.05; n.s. no statistical significance, Welch’st-test (c), Student’s t-test (f)