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. 2019 Jan 25;10(2):65. doi: 10.1038/s41419-019-1347-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Gene Ontology analysis of differentially expressed genes in NSD2-KD cells compared with control cells without cisplatin (left panel) or with cisplatin (right panel). b Real-time quantitative polymerase chain reaction confirmation of NSD2, BCL2, BAD and SOX2 expression in control and NSD2-KD 143B cells (upper panel) and in HOS cells (lower panel). c Western blot analysis of SOX2, BCL2 and NSD2 expression in parental and NSD2-KD OS cells. *P < 0.05 and **P < 0.01 compared with the control group; ^#P < 0.05 and ^##P < 0.01 compared with the cisplatin-treated group