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. 2019 Jan 25;10(2):74. doi: 10.1038/s41419-019-1328-4

Fig. 5. SETD3 catalytic activity is required for p53 recruitment to its target genes following DOX treatment.

Fig. 5

a Chromatin immunoprecipitation (ChIP) assay of control and SETD3 KO HCT-116 cells treated with DOX or vehicle. DNA fragments were immunoprecipitated with p53 antibody. Values were compared to input samples. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. b Chromatin immunoprecipitation (ChIP) assay of control, SETD3 KO and rescued (with WT or Y313A) cells, post DOX treatment. DNA fragments were immunoprecipitated with p53 antibody. Values were compared to input samples. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001