Fig. 4. KDM4B enhances the recruitment of c-Jun to the IL-8 and MMP1 promoters.

ChIP analysis of KDM4B and c-Jun occupancy and H3K9me3 signal on the promoter of IL-8 (a‒c) or MMP1 (d‒f) in non-infected AGS cells or those infected with H. pylori. Chromatin immunoprecipitation (ChIP) was performed with specific antibodies against KDM4B (a, d), c-Jun (b, e), and H3K9me3 (c, f), respectively. AGS cells were infected with H. pylori at an moi of 50 for 3 h, followed by ChIP analysis. Fold enrichments normalized to IgG are presented (mean ± SD from three independent experiments). *p < 0.05; **p < 0.01