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. 2019 Jan 3;116(4):1384–1393. doi: 10.1073/pnas.1812449116

Fig. 3.

Fig. 3.

Reprogramming factors inhibit IRF7Δ response in fibroblasts. (A and B) Overexpression of OCT4, SOX2, and KLF4 with IRF7Δ in 293T cells. RNA was analyzed by qRT-PCR for IFIT1 and ISG15 mRNA expression, represented as fold change and normalized to IRF7Δ alone. Error bars depict the SD of the mean. Significance was determined by unpaired Student’s t test, where ** to **** denote P values of 0.005 to <0.0001, respectively. Horizontal bars denote comparison groups. (C) Heatmap depicting gene expression profiles from 293T cells transfected with KLF4, IRF7Δ, or KLF4 and IRF7Δ. Heatmap represents genes that are significant (adjusted P value <0.05) and have an abs(log2fold change) >1 in any of the three conditions.