Fig. 5.

Transient IRF7Δ expression results in lasting transcriptional changes to iPSCs and affects differentiation potential. (A and B) hPSC ScoreCard results for Dox-treated (A) and differentiated (B) iPSCs. Each sample represents biological duplicates. Colors correlate to the fold change in expression of the indicated gene relative to the undifferentiated reference set, where blue is down-regulated, white is unchanged, and red is up-regulated. (C) Analysis of the transcriptional variation between duplicate samples of untreated iPSCs, Dox-treated iPSCs, and trilineage differentiations by sPCA for GFP and IRF7Δ lines.