Fig. 2.

Joint human–pathogen GWAS reanalysis of viral load in 410 HCV genotype 3a-infected white Europeans (25). All pairs of human nucleotide variants and viral amino acid variants were tested for association. Interactions between human and virus variants’ effects on viral load were not constrained to be additive. (A) Significance of 330,320,340 tests plotted by position of both the human and the viral variants. (B) Significance of 399,420 human variants model averaged using the HMP over every possible interaction with 827 viral variants and vice versa. The significance thresholds controlling the FWER at $\alpha =0.05$ are indicated (black dashed lines): $\alpha /\left(L_H{L}_P\right)$, $\alpha /L_H$, and $\alpha /L_P$.