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. 2019 Jan 25;38:36. doi: 10.1186/s13046-019-1026-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — miR-29a is preferentially expressed in the most aggressive glioblastoma subclasses and promotes glioblastoma growth: a) Consensus clustering microRNA expression heatmap using 121 highly informative microRNA expression profiles from 197 glioblastomas demonstrating the expression of miR-29a (arrow) in the astrocytic and neural subclasses. The microRNA based classification of the tumor specimens is indicated at the top of the diagram, and the mRNA-based classification is indicated at the bottom. b) Median survival of each of the microRNA-based glioblastoma subclasses. c) BrdU proliferation assay illustrating the effect of miR-29a, miR-29b, miR-29c or a control mimic (100 nM) on proliferation in human U87 glioblastoma cells. Mean ± SEM (*P < 0.026, unpaired t-test). d) MTT cell growth assay illustrating the effect of lentiviral-mediated overexpression of miR-29a or a control sequence on the growth of primary human glioblastoma stem-like cells (*P < 0.0001, unpaired t-test)