Table 5.
Univariate COX analysis to determine factors associated with patient survival for PD-L1 expression in tumor cells
| Variables | Overall survival | Disease-free survival | ||||
|---|---|---|---|---|---|---|
| Hazard ratios | 95%CI | P value | Hazard ratios | 95%CI | P value | |
| PD-L1 | ||||||
| Negative | 1 | 1 | ||||
| Positive | 1.240 | 0.929-1.653 | 0.144 | 1.436 | 1.095-1.883 | 0.009 |
| Age | ||||||
| <60 years | 1 | 1 | ||||
| ≥60 years | 1.303 | 0.995-1.705 | 0.054 | 1.205 | 0.932-1.557 | 0.154 |
| Gender | ||||||
| Female | 1 | 1 | ||||
| Male | 1.033 | 0.737-1.448 | 0.849 | 0.942 | 0.684-1.297 | 0.714 |
| Tumor differentiation | ||||||
| Well | 1 | 1 | ||||
| Moderate | 1.383 | 0.954-2.005 | 0.087 | 1.458 | 1.025-2.074 | 0.036 |
| Poor | 2.150 | 1.435-3.222 | <0.001 | 2.180 | 1.478-3.216 | <0.001 |
| Basaloid | 1.774 | 0.828-3.804 | 0.141 | 2.162 | 1.052-4.444 | 0.036 |
| Location | ||||||
| Upper thoracic | 1 | 1 | ||||
| Middle thoracic | 0.872 | 0.602-1.262 | 0.468 | 0.960 | 0.669-1.379 | 0.826 |
| Lower thoracic | 0.798 | 0.529-1.204 | 0.282 | 0.900 | 0.604-1.341 | 0.604 |
| PT status | ||||||
| pT2 | 1 | 1 | ||||
| pT3-4a | 1.348 | 0.984-1.847 | 0.063 | 1.377 | 1.019-1.859 | 0.037 |
| PN status | ||||||
| pN0 | 1 | 1 | ||||
| pN1 | 2.175 | 1.575-3.002 | <0.001 | 2.277 | 1.681-3.084 | <0.001 |
| pN2 | 3.703 | 2.542-5.394 | <0.001 | 3.291 | 2.284-4.744 | <0.001 |
| pN3 | 9.401 | 5.707-15.486 | <0.001 | 8.029 | 4.875-13.225 | <0.001 |
| Vascular invasion | ||||||
| No | 1 | 1 | ||||
| Yes | 1.853 | 1.415-2.427 | <0.001 | 1.714 | 1.326-2.218 | <0.001 |
| Perineural invasion | ||||||
| No | 1 | 1 | ||||
| Yes | 1.707 | 1.297-2.245 | <0.001 | 1.645 | 1.267-2.138 | <0.001 |
| Metachronous hematogenous metastasis | ||||||
| No | 1 | 1 | ||||
| Yes | 2.533 | 1.868-3.435 | <0.001 | 3.638 | 2.716-4.873 | <0.001 |