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. 2019 Jan 25;17:9. doi: 10.1186/s12964-018-0316-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — HOXD10 hypermethylation was associated with lower mRNA expression. a Differential mRNA expression analysis using paired tumor/surrounding tissues identified top 40 differentially mRNA genes. Lower HOXD10 mRNA expression in tumor tissues compare to paired normal tissues. b Differential methylation analysis using paired tumor/surrounding tissues identified top 40 differentially methylated genes. Higher HOXD10 methylation in tumor tissues compare to the counterpart