Fig. 3.

Tiamulin induces plasmatic metabolic variations. a PCA score plot on the first (T1 48%) and the fourth (T4 5%) principal component derived from the model calculated using the 1d-NMR spectra of birds’ plasma at PM2. b Color-coded plot of the plasma 1D-NMR spectra of control birds (blue), infected and non-treated birds (pink) and treated birds (green). c Plot of the principal component 1 (PC1) loadings, molecules pointing up positively correlated with PC1, molecules pointing down negatively correlated with PC1. d Plot of the principal component 4 (PC4) loadings, molecules pointing up positively correlated with PC4, molecule pointing down negatively correlated with PC4. e PCA scores plot derived from the model calculated using the ¹H HR-MAS NMR spectra acquired from intact liver biopsies. f Plot of the loadings of principal component 1 (PC1) of the PCA model presented in E