Table 2.
Comparison of sociodemographic and clinical characteristics for the Gaucher disease population by ERT use, 2014
| ERT+, n (%) n=206 |
ERT–, n (%) n=294 |
P values* | |
| Age group, years | 0.242 | ||
| 0–17 | 15 (7.3) | 32 (10.9) | |
| 18–24 | 8 (3.9) | 14 (4.8) | |
| 25–34 | 31 (15.0) | 26 (8.8) | |
| 35–44 | 48 (23.3) | 55 (18.7) | |
| 45–54 | 26 (12.6) | 36 (12.2) | |
| 55–64 | 31 (15.0) | 49 (16.7) | |
| 65–74 | 35 (17.0) | 38 (12.9) | |
| 75–84 | 9 (4.4) | 35 (11.9) | |
| 85+ | 3 (1.5) | 9 (3.1) | |
| Sex | 0.440 | ||
| Male | 99 (48.1) | 131 (44.6) | |
| Female | 107 (51.9) | 163 (55.4) | |
| Ethnicity† | |||
| Jewish | 196 (95.1) | 272 (92.5) | |
| Non-Jewish | 10 (4.9) | 22 (7.5) | |
| Socioeconomic status | 0.852 | ||
| Low | 41 (19.9) | 52 (17.7) | |
| Medium | 83 (40.3) | 128 (43.5) | |
| High | 72 (35.0) | 102 (34.7) | |
| Missing | 10 (4.9) | 12 (4.1) | |
| Body mass index | 0.189 | ||
| Underweight | 9 (4.4) | 7 (2.4) | |
| Normal | 87 (42.2) | 133 (45.2) | |
| Overweight | 82 (39.8) | 96 (32.7) | |
| Obese | 22 (10.7) | 46 (15.6) | |
| Missing | 6 (2.9) | 12 (4.1) | |
| Smoking habits (adults) | 0.199 | ||
| Never smoker | 146 (76.4) | 177 (67.6) | |
| Former smoker | 24 (12.6) | 40 (15.3) | |
| Current | 19 (9.9) | 41 (15.6) | |
| Missing | 2 (1.0) | 4 (1.5) | |
| Charlson Comorbidity Index | <0.001 | ||
| <1 | 41 (19.9) | 134 (45.6) | |
| 1 to <2 | 77 (37.4) | 51 (17.3) | |
| ≥2 | 81 (39.3) | 96 (32.7) | |
| Missing | 7 (3.4) | 13 (4.4) | |
ERT+, users of ERT; ERT–, non-users of ERT.
*χ2, Fisher’s or trend tests were used to assess differences in distribution between ERT+ and ERT− groups.
†Data were missing for four adults from the Clalit population.
ERT. enzyme replacement therapy.