Table 3.
Trends in renal cell carcinoma Incidence-based mortality Rates (1992-2015)
| Overall (1992-2015) |
Trend | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |||||||||||
| APCa
(95% CI) |
P valueb |
year | APCa
(95% CI) |
P valueb |
year | APCa
(95% CI) |
P valueb |
year | APCa
(95% CI) |
P valueb |
year | APCa
(95% CI) |
P valueb |
|
| Overall | −2.159 (−3.342- -0.962) | .001 | 1992-2001 | 1.092 (0.631-1.555) | <.001 | 2001-2008 | −1.465 (−2.297- -0.625) | .002 | 2008-2013 | −9.282 (−11.013- -7.517) | <.001 | 2013-2015 | −32.242 (−38.991- -24.745) | <.001 |
| Sex | ||||||||||||||
| Male | −2.110 (−3.322- -0.883) | .002 | 1992-2001 | 1.251 (0.732-1.772) | <.001 | 2001-2008 | −1.329 (−2.235- -0.415) | .008 | 2008-2013 | −9.167 (−10.923- -7.376) | <.001 | 2013-2015 | −32.913 (−39.353- -25.789) | <.001 |
| Female | −2.725 (−4.099- -1.331) | .001 | 1992-2006 | 0.143 (−0.343-0.632) | .541 | 2006-2013 | −7.965 (−9.782- -6.112) | <.001 | 2013-2015 | −38.369 (−48.328- -26.492) | <.001 | |||
| Race | ||||||||||||||
| White | −2.505 (−3.691- -1.304) | <.001 | 1992-2001 | 0.850 (0.216-1.488) | .012 | 2001-2008 | −1.949 (−3.117- -0.767) | .004 | 2008-2013 | −9.666 (−11.985- -7.286) | <.001 | 2013-2015 | −33.833 (−42.509- -23.847) | <.001 |
| Black | −1.738 (−3.205- -0.250) | .024 | 1992-/2009 | 0.718 (−0.217-1.661) | .125 | 2009-2015 | −17.216 (−22.175- -11.942) | <.001 | ||||||
| American Indian/Alaska Native | −0.702 (−2.536-1.166) | .441 | 1992-2010 | 1.375 (−0.516-3.301) | .145 | 2010-2015 | −19.902 (−33.518- -3.498) | .022 | ||||||
| Asian or Pacific Islander | 0.586 (−0.854-2.046) | .410 | 1992-2007 | 3.387 (2.793-3.984) | <.001 | 2007-2013 | −4.61 (−7.216- -1.948) | .002 | 2013-2015 | −36.2 (−47.467- -22.736) | <.001 | |||
| Age at death, y | ||||||||||||||
| <65 | −1.606 (−3.225-0.039) | .055 | 1992-2006 | 2.015 (1.363-2.671) | <.001 | 2006-2013 | −5.619 (−7.870- -3.312) | <.001 | 2013-2015 | −37.753 (−46.951- -26.961) | <.001 | |||
| >65 | −2.704 (−3.927- -1.466) | <.001 | 1992-2001 | 0.627 (0.099-1.158) | .024 | 2001-2008 | −2.007 (−2.979- -1.026) | .001 | 2008-2013 | −10.183 (−12.149- -8.172) | <.001 | 2013-2015 | −33.729 (−40.709- -25.926) | <.001 |
| Stage at diagnosisd | ||||||||||||||
| Localized | −3.225 (−5.042- -1.373) | .002 | 1992-2001 | 1.745 (0.893-2.604) | .001 | 2001-2008 | −2.115 (−3.695- -0.509) | .014 | 2008-2013 | −16.099 (−18.729- -13.383) | <.001 | 2013-2015 | −42.356 (−52.584- -29.921) | <.001 |
| Regional | −3.465 (−4.749- -2.164) | <.001 | 1992-2004 | −0.629 (−1.241- -0.013) | .046 | 2004-2012 | −6.111 (−7.848- -4.341) | <.001 | 2012-2015 | −36.292 (−44.120- -27.368) | <.001 | |||
| Distant | 0.046 (−0.856-0.957) | .917 | 1992-2012 | 1.162 (0.553-1.774) | .001 | 2012-2015 | −18.270 (−28.775- -6.215) | .006 | ||||||
| Tumor size, cm | ||||||||||||||
| < 7 | −2.054 (−3.580- -0.505) | .012 | 1992-2001 | 1.967 (1.070-2.873) | <.001 | 2001-2008 | −0.698 (−2.218-0.846) | .345 | 2008-2012 | −11.099 (−15.408- -6.570) | <.001 | 2012-2015 | −28.267 (−34.748- -21.144) | <.001 |
| 7-10 | −2.105 (−3.550- -0.640) | .007 | 1992-2004 | 1.587 (0.464-2.723) | .008 | 2004-2013 | −5.553 (−7.912- -3.134) | < | 2013-2015 | −39.736 (−57.670- -14.204) | .008 | |||
| > 10 | −1.358 (−2.458- -0.246) | .019 | 1992-2002 | 1.574 (0.616-2.541) | .003 | 2002-2013 | −2.427 (−3.375- -1.470) | <.001 | 2013-2015 | −34.826 (−45.828- -21.588) | <.001 | |||
a
Annual Percentage Changes, calculated using Joinpoint regression software
b
Two-sided P value was calculated using t test to determine the significance of APC change
c
Using SEER historic stage A