Table 1.
Summary of solid epithelial cancer datasets
| Mortality Data | Estimated Deaths1 |
TCGA DATASET | TCGA Subtype | ||||
|---|---|---|---|---|---|---|---|
| Rank | Cancer | Dataset [Abbreviation] | # samples | Subtype [Abbreviation] | # samples | N>50 | |
| 1 | Lung and bronchus |
155,870 | Lung Adenocarcinoma [LUAD] | 521 | Lung Adenocarcinoma [LUAD] | 517 | Yes |
| Lung Squamous Cell Carcinoma [LUSC] |
504 | Lung Squamous Cell Carcinoma [LUSC] |
501 | Yes | |||
| 2 | Colorectum | 50,260 | Colon Adenocarcinoma [COAD] | 461 | Colon [Colon] Rectal [Rectal] |
247 94 |
Yes Yes |
| 3 | Pancreas | 43,090 | Pancreatic Adenocarcinoma [PAAD] |
185 | Pancreatic Adenocarcinoma [PAAD] |
170 | Yes |
| 4 | Breast | 41,070 | Breast Invasive Carcinoma [BRCA] |
1097 | Breast Invasive Lobular Carcinoma [BRCA_lobular] |
206 | Yes |
| Breast Invasive Ductal Carcinoma [BRCA_ductal] |
812 | Yes | |||||
| 5 | Liver and intrahepatic bile duct |
28,920 | Cholangiocarcinoma [CHOL] | 36 | Cholangiocarcinoma [CHOL] | 35 | No |
| 6 | Prostate | 26,730 | Prostate Adenocarcinoma [PRAD] |
498 | Prostate [PRAD] | 498 | Yes |
| 7 | Urinary bladder |
16,870 | Bladder Urothelial Carcinoma [BLCA] |
412 | Bladder [BLCA] | 408 | Yes |
| 8 | Esophagus | 15,690 | Esophageal Carcinoma [ESCA] | 185 | Esophageal Adenocarcinoma [ESCA_AD] |
89 | Yes |
| Esophageal Squamous Cell Carcinoma [ESCA_SCC] |
96 | Yes | |||||
| 9 | Ovary | 14,080 | Ovarian Serous Cystadenocarcinoma [OV] |
586 | Papillary Serous Carcinoma or Serous Ovarian Cancer [OV] |
303 | Yes |
| 10 | Stomach | 10,960 | Stomach Adenocarcinoma [STAD] |
443 | Stomach Adenocarcinoma [STAD] |
230 | Yes |
| 11 | Uterine corpus |
10,920 | Uterine Corpus Endometrial Carcinoma [UCEC] |
548 | Uterine Endometrial Carcinoma [UEC] |
119 | Yes |
| Uterine Serous Carcinoma/Uterine Papillary Serous Carcinoma [USC] |
58 | Yes | |||||
| 12 | Oral cavity and pharynx |
9,700 | Head and Neck Squamous Cell Carcinoma [HNSC] |
528 | Head and Neck Squamous Cell Carcinoma [HNSCC] |
522 | Yes |
| 13 | Cervix | 4,210 | Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma [CESC] |
307 | Cervical Squamous Cell Carcinoma [CESC_SCC] |
253 | Yes |
| Endocervical Adenocarcinoma or Mucinous Carcinoma [CESC_AD] |
44 | No | |||||
Top 13 solid epithelial tumors ranked by estimated deaths in 2017. TCGA datasets corresponding to the top cancers were matched and the total number of samples with RNAseqV2 data available is indicated. Using clinical annotations, the TCGA datasets were refined to reflect predominant subtypes. The number of samples utilized is indicated for each subtype. The 17 cancer subtypes with n ≥ 50 samples were used in downstream solid tumor analysis.
1
Source: Estimated 2017 deaths based on 2000–2014 United States mortality data. ACS. https://cancerstatisticscenter.cancer.org/#/