Table 2A.
Top ten lung adenocarcinoma and squamous cell carcinoma genes that are differentially correlated with NOTCH1 in the LUAD and LUSC datasets
| LUAD dataset (Top 10) | ||
|---|---|---|
| Gene Symbol | Full Name | Function |
| MMRN2 | Multimerin 2 | Negative regulator of blood vasculature and angiogenesis, cell motility |
| VWF | Von Willebrand factor | Hemostasis, response to wound healing, innate immune system, cell adhesion, macromolecular complex binding, platelet activation |
| CDH5 | Cadherin 5, type 2 (vascular endothelium) | Vasculature and blood vessel development, negative regulation of cell proliferation, cell adhesion |
| ARHGEF15 | Rho guanine nucleotide exchange factor (GEF) 15 |
GEF for RhoA activation, regulator of vascular development GTPase regulator, and guanyl nucleotide exchange factor |
| CD93 | CD93 molecule | Intercellular adhesion, regulation of immune and defense response, leukocyte activation, and immune effector process |
| GIMAP8 | GTPase, IMAP family member 8 | Anti-apoptotic effect in immune system, mitochondrion |
| SH2D3C | SH2 domain containing 3C | Cell migration, GTPase, guanyl-nucleotide exchange factor, kinase binding, immune function |
| NOTCH4 | NOTCH4 | Vasculature and blood vessel development, angiogenesis, innate immune system |
| CLEC14A | C-type lectin domain family 14, member A | Cell-cell adhesion, angiogenesis, lymphangiogenesis |
| ROBO4 | Roundabout, axon guidance receptor, homolog 4 (Drosophila) |
Angiogenesis, vascular patterning, blood vessel development, [inhibition of] cell migration, modulate vascular response to inflammatory cytokines |
| LUSC dataset (Top 10) | ||
| Gene Symbol | Full Name | Function |
| B4GALNT4 | beta-1,4-N-acetyl-galactosaminyl transferase 4 |
Metabolism, transferase activity, mitotic spindle |
| LHX2 | LIM homeobox 2 | Macromolecular complex binding, chromatin binding, cell differentiation |
| ASPM | Asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
Mitotic cell cycle regulation and coordination, cell cycle, nuclear division, microtubule cytoskeleton |
| NUSAP1 | Nucleolar and spindle associated protein 1 | Spindle microtubule organization, cell cycle, mitotic cell cycle and process, cell division, microtubule cytoskeleton, macromolecular complex binding, RNA binding, chromosome organization and segregation |
| DTL | Denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
Cell cycle control, microtubule cytoskeleton and organizing center, chromosome, centrosome, DNA damage response |
| TFAP2A | Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha |
Microtubule cytoskeleton, centrosome, macromolecular complex binding, chromatin binding |
| TOP2A | Topoisomerase (DNA) II alpha | Makes double strand breaks, segregation of daughter chromosomes, macromolecular complex binding, cell cycle, chromosome, mitotic cell cycle, RNA binding, chromatin |
| KNTC1 | Kinetochore associated 1 | Component of mitotic checkpoint, cell cycle, chromosome, nuclear division, cell division, chromosomal segregation, microtubule cytoskeleton |
| KIF14 | Kinesin family member 14 | Cell cycle, mitosis, nuclear and cell division, cytokinesis, chromosomal segregation, cell proliferation, apoptosis, microtubule, macromolecular complex binding, sister chromatid segregation |
| HNRNPK | Heterogeneous nuclear ribonucleoprotein K |
Pre-mRNA binding protein, response to DNA damage |