Table 2B. Summary of the top three distinct pathways correlated with NOTCH1 in the LUAD and LUSC datasets.
Gene list enrichment analysis based on functional annotations was performed using probability density function method, FDR P-value cutoff 0.05; Toppgene (https://toppgene.cchmc.org/). P-values are shown in Supplemental Table 4 and 5.
| Distinct pathways in LUAD dataset (Top 3) | ||
|---|---|---|
| Pathway | Terms (Top 3) | GO/BioSystems ID (Top 3) |
| Angiogenesis and vasculature development |
vasculature development, blood vessel development, response to wounding |
GO: 0001944, 0001568, 0009611 |
| Immune System | regulation of defense response, regulation of immune system process, leukocyte activation |
GO: 0031347, 0002682, 0045321 |
| Rho/GTPase | signaling by Rho GTPases, Rho GTPase cycle, RHO GTPases Activate Formins |
BioSystems: REACTOME: 1269507, 1269508, 1269519 |
| Distinct pathways in LUSC dataset (Top 3) | ||
| Pathway | Terms (Top 3) | GO/BioSystems ID (Top 3) |
| Cell cycle | cell cycle, cell cycle process, mitotic cell cycle |
GO: 0007049, 0022402, 0000278 |
| Macromolecular complex binding |
microtubule cytoskeleton, macromolecular complex binding, spliceosomal complex |
GO: 0015630, 0044877, 0005681 |
| Chromosome | chromosome organization, sister chromatid segregation, chromatin binding |
GO: 0051276, 0000819, 0003682 |