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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Cell Signal. 2018 Dec 10;55:17–25. doi: 10.1016/j.cellsig.2018.12.004

Figure 6.

Figure 6.

A) Total number of significantly differentially expressed genes (P < 0.01) in cells treated with 25, 50 and 100 μM of SC-514 compared to untreated cells at 15, 30, 60, 120, and 360 min after TNF-α (10 ng/ml) stimulation. An increasing number of differentially expressed genes is seen with increasing concentration of SC-514 for each individual time point. B) Log2 fold change in gene expression in cells treated with 25, 50 and 100 μM of SC-514 compared to untreated cells for six inflammatory genes Il1r1, Il6, Cox2, Nfkbia, Tnfaip3 and Egr1 at 15, 30, 60, 120, and 360 min after TNF-α (10ng/ml) stimulation. Significance (P < 0.05) indicated in red Note vertical axis are different for each gene.