Table 5.
Change from Baseline within Treatment Group* | ||||||
Estimate (95% Confidence interval) P-value | ||||||
Periocular | Intravitreal | Dexamethasone | ||||
Week 4 | 2.78 (0.20, 5.36) | 0.034 | 10.14 (7.59, 12.69) | <0.0001 | 7.28 (4.45, 10.10) | <0.0001 |
Week 8 | 4.37 (1.86, 6.89) | 0.0007 | 9.70 (7.26, 12.13) | <0.0001 | 9.53 (7.01, 12.05) | <0.0001 |
Week 12 | 4.67 (2.14, 7.21) | 0.0003 | 10.43 (7.67, 13.18) | <0.0001 | 7.24 (4.34, 10.14) | <0.0001 |
Week 20 | 5.17 (1.89, 8.46) | 0.002 | 9.88 (6.72, 13.04) | <0.0001 | 7.67 (5.23, 10.11) | <0.0001 |
Week 24 | 4.07 (0.64, 7.51) | 0.020 | 9.60 (6.87, 12.34) | <0.0001 | 9.21 (6.62, 11.80) | <0.0001 |
Difference in Change from Baseline between Treatment Groups* | ||||||
Estimate (95% Confidence interval) P-value | ||||||
Intravitreal - Periocular | Dexamethasone - Periocular | Dexamethasone Intravitreal | ||||
Week 4 | 7.36 (3.74, 10.98) | <0.0001 | 4.49 (0.67, 8.31) | 0.021 | −2.86 (−6.66, 0.94) | 0.14 |
Week 8 | 5.32 (1.82, 8.82) | 0.003 | 5.16 (1.60, 8.72) | 0.004 | ࢤ0.16 (−3.67, 3.34) | 0.93 |
Week 12 | 5.75 (2.01, 9.49) | 0.003 | 2.57 (−1.28, 6.42) | 0.19 | ࢤ3.19 (−7.19, 0.81) | 0.12 |
Week 20 | 4.71 (0.16, 9.26) | 0.042 | 2.50 (−1.59, 6.58) | 0.23 | ࢤ2.21 (−6.20, 1.78) | 0.28 |
Week 24 | 5.53 (1.14, 9.92) | 0.013 | 5.14 (0.84, 9.44) | 0.019 | ࢤ0.40 (−4.16, 3.37) | 0.84 |
An improvement of 15 letters (3 lines) corresponds to halving of the visual angle.