Figure 14.

Pharmacological manipulation of AChE expression/activity may have potential applications in lung cancer therapy. AChE modulators like miR-212 and Aβ-peptide fragments increase the expression (and activity) of AChE, which in turn accelerates the degradation of acetylcholine (ACh) in human lung cancer cells. Such a decline in ACh levels decreases its tumor promoting activities like proliferation, induction of EMT and invasion potentially suppressing the progression of human lung cancers.