Table 9.
Expression of muscarinic receptors in normal human bronchial epithelial cells and lung cancer cell lines
| Cell line | Nature of cells | Nature of muscarinic receptor | Referenc e |
||||
|---|---|---|---|---|---|---|---|
| M1R | M2R | M3R | M4R | M5 R |
|||
| BEP2D | Immortalized normal human bronchial epithelium |
+ | 128 | ||||
| 16-HBE | Immortalized normal human bronchial epithelium |
+ |
5, 213 |
||||
| HLF | Human lung fibroblasts |
+ | 177, 254 | ||||
| SCC-15, SCC-9 |
Small cell lung cancer |
+ | 257, 346- 348 |
||||
| SBC3 | Small cell lung cancer |
+ | 31, 369 | ||||
| NCI-H146 | Small cell lung cancer |
+ | 346 | ||||
| NCI-H209 | Small cell lung cancer |
+ | 346 | ||||
| H69, H82, H345, H592, H417, H1694 |
Small cell lung cancer |
+ | + | + | + | + | 300, 301 |
| H398 | Small cell lung cancer |
+ | + | 300 | |||
| H157 | Squamous cell carcinoma |
+ | + | + | + | + | 128 |
| L78, SPCA-1 | Squamous cell carcinoma |
+ | 177 | ||||
| A549, PC9 | Lung adenocarcinoma |
+ | + | + | + | + | 128, 177, 376, 377 |
| GLC82 | Lung adenocarcinoma |
+ | 177 | ||||
| H1299, H460 | Lung adenocarcinoma |
+ | + | + | + | + | 128 |
(Blanks indicate Not Determined (ND)