Fig. 5.

In vivo effect of BI 853520 in orthotopically growing human MPM xenografts. a P31 cells were orthotopically injected into SCID mice. Following 28 days of tumor inoculation, 20 mg/kg BI 853520 or solvent was administered orally for 3 weeks five times per week. After treatment, mice were sacrificed and their MPM tumor load was quantified. Tumor-bearing mice treated with BI 853520 had significantly lower tumor loads (vs. solvent-treated controls; *P = 0.0183). b Relative body weight was decreased by the time of termination, but no significant difference was found between BI 853520- and solvent-treated animals. c Microscopy images of representative hematoxylin and eosin (H&E) staining in MPM xenograft tumors of either BI 853520- or solvent-treated mice. Scale bar 100 μm