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. 2018 Dec 11;97(2):231–242. doi: 10.1007/s00109-018-1725-7

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — BI 853520 inhibits tumor cell proliferation and angiogenesis in orthotopically growing human MPM in mice. a Representative images of Ki67 immunohistochemistry in MPM xenograft tumors of either BI 853520- or solvent-treated tumor-bearing mice. Scale bar 100 μm. b Quantification of Ki67-labeling indicates significant inhibitory effect of BI 853520 treatment on MPM cell proliferation (P = 0.0012). c Impact of BI 853520 treatment on tumor angiogenesis. Representative immunofluorescence images of frozen sections from control and BI 853520-treated tumors labeled with DAPI (blue) and anti-CD31 Ab (green). d There was a significant reduction in microvessel densities (MVDs) in the BI 853520-treated (20 mg/kg) group (P = 0.0159)